Nestin is a type of protein found in neural stem cells, which are undifferentiated cells that can transform into various types of mature neural cells such as neurons, astrocytes, and oligodendrocytes. Nestin plays a crucial role in the maintenance of neural stem cells by regulating their proliferation, differentiation, and migration. It is considered a marker of neural progenitor cells and is often used to identify and isolate these cells for research purposes. Nestin is also expressed in other types of cells such as skeletal and muscle cells, and is associated with tissue repair and regeneration. Its expression has been linked to various neurological disorders, and recently, some studies have shown its potential as a therapeutic target for neurodegenerative diseases.
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